Premium
The expression of HLA‐DR on keratinocytes in oral lichen planus
Author(s) -
Hedberg N. M.,
Hunter N.
Publication year - 1987
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1987.tb00673.x
Subject(s) - oral lichen planus , hla dr , keratinocyte , immunofluorescence , histocompatibility , pathology , antigen , oral mucosa , epithelium , monoclonal antibody , immunology , human leukocyte antigen , biology , antibody , medicine , cell culture , genetics
HLA‐DR is a Class FI histocompatibility antigen which has recently been reported to occur in increased amounts in dermal and oral lichen planus. Its expression in epithelium was previously thought to be limited to Langerhans cells. In this study, formalin‐fixed sections of oral lichen planus and a variety of other oral mucosal lesions were stained with a monoclonal antibody to HLA‐DR using an indirect immunofluorescence test. The expression of HLA‐DR by keratinocytes did not appear to be a specific marker for lichen planus as demonstrated by the reactivity of the epithelium in a variety of lesions of the oral mucosa. II HLA‐DR expression is considered to be an inducible function, perhaps in response to γ interferon secreted by activated lymphocytes, then keratinocyte reactivity would not be expected to occur only in lichen planus.