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Differential expression of Class II (DR & DQ) antigens by human gingival Langerhans' cells and keratinocytes in vitro
Author(s) -
Walsh L. J.,
Seymour G. J.,
Powell R. N.
Publication year - 1987
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1987.tb00672.x
Subject(s) - immunoperoxidase , fusobacterium nucleatum , antigen , in vitro , keratinocyte , immunofluorescence , gingivitis , epithelium , pathology , microbiology and biotechnology , biology , immunology , medicine , chemistry , porphyromonas gingivalis , antibody , periodontitis , monoclonal antibody , dentistry , biochemistry
The expression of the Class II products DR and DQ on human gingival epithelium was examined using immunofluorescence and immunoperoxidase staining. Differential expression of Class II antigens was seen in chronic gingivitis in adults, with T6(+) DR(+) cells being more numerous than T6(+) DQ(+) cells. The periodontopathic organism Fusobacterium nucleatum (FN) induced DQ expression on Langerhans' cells (LC) during in vitro explain culture of gingival tissue. This effect was mimicked by endotoxin (LPS) from F. nucleatum and by E. coli LPS. These results indicate that differential expression of Class II products, a feature of chronic gingival inflammation, may result from the action of LPS on gingival LC.