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Human papillomavirus Type 2 DNA in oral verrucous carcinoma
Author(s) -
AdlerStorthz K.,
Newland J. R.,
Tessin B. A.,
Yeudall W. A.,
Shillitoe E. J.
Publication year - 1986
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1986.tb00661.x
Subject(s) - verrucous carcinoma , human papillomavirus , carcinoma , medicine , papillomaviridae , dermatology , pathology , dna , cancer research , biology , cancer , genetics , cervical cancer
Tissues from patients with oral verrucous carcinoma were examined for the presence of human papillomavirus (HPV). The tissues were stained for the presence of the type common papillomavirus antigen by immunohistochemical staining and the presence of HPV DNA was determined by in situ hybridization with biotin‐labelled HPV DNA probes. Seventeen tissue specimens were obtained from 9 patients, and included pre‐malignant lesions and primary and recurrent tumors. One pre‐malignant lesion was positive for papillomavirus structural antigen. This lesion and lesions from 2 other patients hybridized at low stringency (T m ‐35°) to 3 different HPV probes. By hybridization under high stringency conditions (T m ‐20°), the virus in each case was identified as being HPV2.