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Adenoid cystic carcinoma of the salivary glands: an immunohistochemical study
Author(s) -
Caselitz J.,
Schulze I.,
Seifert G.
Publication year - 1986
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1986.tb00631.x
Subject(s) - myoepithelial cell , pathology , immunohistochemistry , adenoid cystic carcinoma , ductal cells , salivary gland , biology , basement membrane , cribriform , stromal cell , clear cell , carcinoma , medicine
Twenty‐four cases of adenoid cystic carcinoma from the Salivary Gland Registry of the University of Hamburg were analysed with respect to their differentiation and subclassification. With immunohistochemical methods, several groups of marker substances were analysed in these tumors: marker for a glandular function; immunoglobulins; metalloproteins; tumor markers; substances associated with the basal membrane and carbohydrate chains. The following patterns of histological differentiation were found: cribriform pattern with typical pseudocysts; tubular pattern with ductal elements; trabecular pattern with predominance of hyalininzed stromal elements; basaloid pattern with low differentiated cells. For every pattern, a special immunohistochemical profile could be established. The morphological and immunohistochemical analysis revealed the following relation between the different patterns: Origin of the malignant proliferation is presumably the terminal ductal system of the salivary glands (indifferent cell of the reserve cell type). This cell can differentiate in 2 directions: a myoepithelial and a ductal cell type. Immunohistochemically, the presence of basement membrane‐associated substances is accompanied by the appearance of myoepithelial‐like cells. The presence of secretory products is a feature of ductal cells.