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Growth and acid production of Candida species in human saliva supplemented with glucose
Author(s) -
Samaranayake L. P.,
Hughes A.,
Weetman D. A.,
MacFarlane T. W.
Publication year - 1986
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1986.tb00617.x
Subject(s) - saliva , candida glabrata , candida albicans , microbiology and biotechnology , biology , fungi imperfecti , pathogenesis , biochemistry , immunology
Growth characteristics and acid production of oral isolates of Candida albicans and Candida glabrata in glucose supplemented and glucose‐free, pooled, human whole saliva were examined. Both Candida species exhibited sigmoidal growth curves in hatch cultures of mixed saliva, supplemented with glucose. The growth of Candida in saliva was accompanied by a rapid decline in pH from 7.5 to 3.2 over 48 h and the major acidic components initiating and sustaining this pH drop were pyruvates and acetates. These acidic metabolites may play an important role in the pathogenesis of oral Candida infections.