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Effect of cholera toxin on the induction of gamma‐glutamyl transpeptidase‐positive clones by benzo(a)pyrene in embryonic mouse tongue cells in culture
Author(s) -
Rao K. V. K.,
Gujarathi K. G.,
Bhide S. V.
Publication year - 1986
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1986.tb00607.x
Subject(s) - cholera toxin , toxin , embryonic stem cell , biology , cell culture , carcinogen , cholera , microbiology and biotechnology , cell , biochemistry , genetics , gene
Abstract The utility of gamma‐glutamyl transpeptidase (GOT) as a histochemical marker to study the carcinogen‐induced changes and its possible modulation by cholera toxin was explored in primary cell cultures. It was observed that cholera toxin not only promotes growth of fibroblasts in primary cell culture, but it also enhances the GGT‐positive foci induced by benzo(a)pyrene. It is interesting to speculate that cholera toxin may be acting as a tumor promoter in primary cell cultures of embryonic mouse tongue.