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An ultrastructural study of binucleate plasma cells
Author(s) -
JinnFei Y.,
EILabban N. G.
Publication year - 1986
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1986.tb00589.x
Subject(s) - endoplasmic reticulum , cytoplasm , ultrastructure , binucleated cells , biology , basophilic , plasma cell , membrane , heterochromatin , microbiology and biotechnology , golgi apparatus , nuclear membrane , cell nucleus , pathology , chemistry , anatomy , biochemistry , chromosome , immunology , bone marrow , medicine , micronucleus , micronucleus test , gene , organic chemistry , toxicity
Fifty surgical specimens from 10 different diseases were examined for the presence of binucleate plasma cells. Thirty‐three specimens showed binucleated plasma cells. Morphologically, they resembled mononuclear cells and contained abundant basophilic cytoplasm which ultra‐structurally showed extensive rough endoplasmic reticulum. Their 2 nuclei exhibited the “cart‐wheel” arrangement of heterochromatin characteristic of plasma cells. When serially examined the 2 nuclei remained separate. In addition, pairs of closely apposed plasma cells were observed. Some of these cells showed distinct opposing membranes separated by a gap of approximately 15nm. While others, exhibited localised areas of indistinct membranes. There were also pairs of closely apposed plasma cells showing cytoplasmic bridges. These results suggest that the mode of formation of binucleate plasma cells is probably cell fusion. They also show that these binucleate cells are not confined to a single disease as they were found in 10 different diseases.