Premium
Analysis of HLA antigens in Japanese with oral lichen planus
Author(s) -
Watanabe T.,
Ohishi M.,
Tanaka K.,
Sato H.
Publication year - 1986
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1986.tb00571.x
Subject(s) - oral lichen planus , human leukocyte antigen , antigen , medicine , haplotype , immunology , relative risk , biology , gene , genotype , genetics , confidence interval
Analysis of HLA antigens was performed in 42 Japanese patients with oral lichen planus (OLP). There were no significant differences in the frequency of HLA‐A, B, C antigens between OLP‐patients and control subjects, although a decreasing trend in the frequency of Bw 52 and an increasing trend in that of Bw 61 and Cw 3 was noted. Among the HLA‐DR and DQ antigens studied, the frequency of DRw 9 was significantly increased (Pc<0.05, RR = 3.3) and the relative risk was increased (RR = 6.0) when DRw 9 was carried on as a Bw 61/DRw 9 haplotype. Our results suggest that HLA‐associated genetic factors play a role to some extent in the development of OLP.