Premium
Clear cell odontogenic tumor: histochemical and ultrastructural features
Author(s) -
Eversole L. R.,
Belton C. M.,
Hansen L. S.
Publication year - 1985
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1985.tb00537.x
Subject(s) - biology , pathology , ultrastructure , organelle , cytoplasm , endoplasmic reticulum , ameloblast , stroma , odontogenic tumor , acid phosphatase , anatomy , microbiology and biotechnology , lesion , enamel paint , immunohistochemistry , biochemistry , enzyme , medicine , dentistry
Clear cell odontogenic tumor, a rare epithelial jaw lesion of putative odontogenic origin, histologically resembles clear cell adenocarcinomas. Ultrastructural and histochemical features are described and support a non‐glandular derivation. The intraosseous neoplasm is characterized by ovoid nests of clear or finely stippled cells with a mature collagenous stroma. These cells arc PAS‐positive. diastase labile and fail to bind alcian blue. Enzyme histochemical reactions disclose dehydrogenase. non‐specific csterase. and acid phosphatase positively. Fine structural characteristics include plasma membrane microvilli, desmosomes. endoplasmic reticulum. free ribosomes. glycogen rosettes and lysosomes. Many cells exhibit a paucity of cytoplasmic organelles with prominent vacuolization. Centrioles and annulate lamellae are also encountered. Summarily, clinical, radiographic. histochemical and ultra‐structural features indicate that this neoplasm is probably of epithelial odontogenic origin with cytodifferentiation emulating glycogen‐rich presecretory ameloblasts.