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Lymphocyte function in recurrent aphthous ulceration
Author(s) -
Greenspan J. S.,
Gadol N.,
Olson J. A.,
Hoover C. I.,
Jacobsen P. L.,
Shillitoe H. J.,
Armitage G. C.
Publication year - 1985
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1985.tb00536.x
Subject(s) - pathogenesis , immunology , antigen , immune system , medicine , t lymphocyte , lymphocyte , t cell , delayed hypersensitivity
Lymphocyte blast transformation responses to mitogens and to streptococcal, adenovirus Type I, and oral mucosal antigens were studied in 32 patients with recurrent aphthous ulceration (RAU) and matched control subjects. RAU patients showed significantly depressed (p<0.05) responses to mitogens in comparison with matched controls, but there was no significant difference between patients and controls in response to any of the antigens tested, These results indicate that neither cell‐mediated hypersensitivity to streptococcal or viral antigens nor cross‐reactivity between oral mucosal and streptococcal antigens are likely lo play a role in the pathogenesis of RAU. Rather, the data support the hypothesis of an imbalance or defect in immune cell subpopulations.