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Macrophages in oral lichen planus
Author(s) -
Matthews J. B.,
Basu M. K.,
Potts A. J. C.
Publication year - 1985
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1985.tb00528.x
Subject(s) - basement membrane , oral lichen planus , lamina propria , immunoperoxidase , basal lamina , epithelium , pathology , biology , macrophage , peripheral blood mononuclear cell , lysozyme , basal (medicine) , oral mucosa , pathogenesis , immunology , medicine , ultrastructure , in vitro , antibody , biochemistry , insulin , monoclonal antibody , endocrinology
The presence and distribution of macrophages within 15 non‐ulcerated lesions of oral lichen planus was investigated using an immunoperoxidase technique for the detection of the macrophage markers lysozyme and α 1 antitrypsin. All specimens contained mononuclear lysozyme and α 1 antitrypsin positive cells which were concentrated in a band immediately beneath the epithelium and often associated with areas of damaged basal cells. Cell counts revealed that 11% of the positive cells were in the epithelium and 89% in the lamina propria. Approximately 61% of all positive cells were found within a 125 μm wide zone centred on the basement membrane. These results suggest that in oral lichen planus macrophages are in close proximity to the epithelial basal cells, where cell damage occurs, and play a role in the pathogenesis of his condition.