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Langerhans cell surface densities in rat oral mucosa and human buccal mucosa
Author(s) -
Ahlfors E. E.,
Laksson P. Å.,
Bergstresser P. R.
Publication year - 1985
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1985.tb00510.x
Subject(s) - buccal mucosa , oral mucosa , tongue , epithelium , pathology , langerhans cell , biology , buccal administration , anatomy , chemistry , antigen , medicine , dentistry , immunology , oral cavity , bioinformatics
We determined surface densities of Langerhans cells (LCs) in rat oral mucosa and human buccal mucosa by enumerating ATPase‐positive dendritic cells in epithelial whole mounts. For the rat, mean surface densities per mm 2 were 160 in anterior buccal mucosa, 640 in posterior buccal mucosa, 430 in the palate and 340 in the tongue. Human buccal mucosa showed a density of 890 cells per mm 2 . We conclude that LC densities in oral mucosa approximate those of external body sites, making them available in numbers sufficient to accomplish their postulated antigen‐presenting functions.