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Relative conversion of arachidonic acid through lipoxygenase and cyclooxygenase pathways by homogenates of diseased periodontal tissues
Author(s) -
Attar T. M. A.,
Lin H. S.
Publication year - 1983
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1983.tb00311.x
Subject(s) - arachidonic acid , lipoxygenase , cyclooxygenase , metabolite , arachidonic acid metabolism , biochemistry , chemistry , metabolism , periodontal disease , enzyme , medicine
The present study shows that 14 C‐arachidonic acid metabolism in gingiva of patients with periodontal disease is mainly via the lipoxygenase pathway. In two pools of gingival tissue homogenates the lipoxygenase products contained 22.65% and 23.38%, while the prostaglandins (PGs), products of the cyclooxygenase pathway, contained only 4.85% and 3.98% of the total radioactivity incubated. 12‐hydroxy‐eicosatetraenoic acid (12‐HETE), a lipoxygenase product, was detected as a major metabolite of arachidonic acid in gingiva.