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An ultrastructural and immunohistochemical study on mandibular lesion of Letterer‐Siwe disease
Author(s) -
Ide Fumio,
Sano Reiji,
Shimura Hitoshi,
Kusama Kaoru,
Umemura Shinichiro
Publication year - 1981
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1981.tb01290.x
Subject(s) - histiocyte , pathology , ultrastructure , immunohistochemistry , lesion , cytoplasm , langerhans cell , electron microscope , biology , cell type , cell , medicine , microbiology and biotechnology , antigen , immunology , physics , genetics , optics
A mandibular lesion from an infant with Letterer‐Siwe disease was studied by electron microscopy and immunohistochemistry. Ultrastructurally, two types of cells were identified; clear and dark cells. Clear cells had indented nuclei and Langerhans cell granules, while dark cells were characterized by the occasional presence of a large number of lysosomes. Lysozyme was usually not detectable in proliferating cells with indented nuclei, but it was strongly positive in cells without indented nuclei. The latter also usually contained IgG, although the occurrence of cytoplasmic IgM, A, D and E seemed to be negative in both types of cells. Thus clear cells showed a close resemblance to Langerhans cells and dark cells had features of ordinary histiocytes. Although the intimate relationship between these two types of cells remains obscure, our findings suggest that Letterer‐Siwe disease may be a reactive or tumorous condition of a cellular subpopulation of Langerhans cells with a proliferation of differentiated histiocytes.