Premium
Morphologic changes in rat parotid following isoproterenol administration and fractionated X‐irradiation
Author(s) -
Nicolatou Ourania E.
Publication year - 1981
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1981.tb01283.x
Subject(s) - parotid gland , irradiation , hyperplasia , connective tissue , pathology , chemistry , endocrinology , medicine , nuclear physics , physics
The effects of fractionated X‐irradiation following isoproterenol (1PN) administration on rat parotid gland were studied 4, 8, and 12 weeks post‐irradiation. Degenerative and necrotic changes of the acinar cells were observed at all three time intervals as a result of the radiation. These changes were more obvious 4 and 8 weeks post‐irradiation and isoproterenol administration. The necrotic acinar cells were replaced by fibrous connective tissue, especially conspicuous at 12 weeks. Reparative changes were observed along with the degenerative and regressive phenomena of the gland. Enlarged acinar cells and nuclei were observed as early as 4 weeks post‐irradiation. This change was locally distributed at the 4–week interval but more widespread 8 and 12 weeks post‐irradiation. Mitochondria! hyperplasia with alteration of mitochondria! cristae was observed 12 weeks post‐irradiation. Proliferation of cells of ductal origin and nodular proliferation of ducts were observed 12 weeks after isoproterenol administration plus X‐irradiation. These proliferative phenomena may represent an early stage of tumor formation resulting from the combined effect of isoproterenol and X‐irradiation on rat parotid gland.