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Permeability of gingival sulcular epithelium in the development of scorbutic gingivitis
Author(s) -
Alvares Olav,
Siegel Ivens
Publication year - 1981
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1981.tb01246.x
Subject(s) - gingivitis , ascorbic acid , epithelium , pathogenesis , dentistry , medicine , urea , biology , pathology , biochemistry , food science
Young adult nonhuman primates were initially fed an ascorbic‐acid free diet and, subsequently, a diet with a suboptimal level of the vitamin. Following approximately 12 weeks of this dietary regime, five of seven experimental animals developed scorbutic gingivitis. 2 to 3 weeks prior to this stage, the permeability of the gingival sulcular epithelium to 3 Hinulin, but not to 14 C‐butyric acid or 14 C‐urea, had increased significantly (+86%, P < 0.01) in the experimental group as compared to ad libitum or pair‐fed controls. This defect in the intercellular permeability barrier of the sulcular epithelium could have contributed to the pathogenesis of scorbutic gingivitis.