Premium
Epithelial cell kinetics – A review of methods of study and their application to oral mucosa in health and disease
Author(s) -
Scragg Margaret A.,
Johnson N. W.
Publication year - 1980
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1980.tb00389.x
Subject(s) - in vivo , cell , disease , pathology , mitosis , pathogenesis , epithelium , oral mucosa , biology , medicine , cancer research , microbiology and biotechnology , biochemistry , genetics
Despite extensive investigation of cell kinetic parameters in a wide range of normal and abnormal tissues and their potential value in understanding the pathogenesis of many disease states, as well as in prognosis and treatment planning, their application to oral epithelia remains limited. In part A the methods most commonly applied to the study of epithelial cell kinetics, i.e., isotope labelling, mitotic arrest and flow cytophotorimetry are reviewed with special emphasis on their technical limitations, sources of variation and inapplicability to humans in vivo. The ability of in vitro methods to reliably reproduce in vivo cell kinetic parameters is also considered. The application of cell kinetic studies to normal and abnormal oral tissues will be discussed in part B.