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Effects of isoproterenol on chemical carcinogenesis with DMBA in mouse salivary glands
Author(s) -
Okada Yukio
Publication year - 1979
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1979.tb01837.x
Subject(s) - dmba , salivary gland , carcinogenesis , carcinogen , endocrinology , medicine , olive oil , saline , isoprenaline , chemistry , cancer , pathology , biochemistry , stimulation , food science
. Histopathological studies were conducted on experimental carcinogenesis in mouse salivary glands using D L‐isoproterenol hydochloride (isoproterenol) and 9 10‐dimethyl‐1 2‐benzantliracene (DMBA). DM BA was admisistered once at 1 mg/0.02 ml in olive oil to the salivary glands, and isoproterenol was injected intraperitoneally at 1 mg/0.05 ml saline solution three times a week for 2 weeks al different periods during the oncogenic process. Salivary glands treated with carcinogen showed a relatively constant sequence of changes and developed epithelial and mesenchymal tumors irrespective of isoproterenol administration. Isoproterenol did not influence the development of another type of tumor; however, it did retard the oncogenic processes.