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Double‐blind trial of tetracycline in recurrent aphthous ulceration
Author(s) -
Graykowski Edward A.,
Kingman Albert
Publication year - 1978
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1978.tb01605.x
Subject(s) - tetracycline , medicine , placebo , incidence (geometry) , double blind , surgery , dermatology , gastroenterology , antibiotics , pathology , physics , alternative medicine , optics , microbiology and biotechnology , biology
A double‐blind trial of a tetracycline suspension was carried out in 25 patients with recurrent aphthous oral ulcerations. A combined topical‐systemic treatment procedure was used. Both the placebo and tetracycline groups experienced reductions in ulcer incidence during the treatment period, whereas only the tetracycline group showed significant reductions in ulcer duration, size, and pain. Tetracycline treatment apparently alters the severity of the ulcer, but does not appear to affect those factors responsible for recurrences. The side effects recorded in patients taking tetracycline were comparable to those in patients on placebo.