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Histochemical study of labial salivary glands in Sjögren's Syndrome
Author(s) -
FavaDeMoraes F.,
Friedman H.,
Egami M. I.,
Bevilacqua E. M. A. F.,
Cossermelli W.
Publication year - 1978
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1978.tb01589.x
Subject(s) - pathogenesis , sjögren syndrome , salivary gland , connective tissue , immunohistochemistry , pathology , medicine , salivary gland diseases , immunopathology , systemic disease , endocrinology
Human labial salivary gland biopsies of patients presenting connective tissue diseases associated with Sjögren's syndrome were submitted to a polysaccharide histochemistry study. The normal acinar secretion is an association of neutral polysaccharides with a sulphosialomucin. In Sjögren's syndrome, there is a great reduction in the secretory activity of the acinar cells, but no qualitative change was observed. The pathogenesis of this decreased production and its importance regarding the clinical manifestations of Sjögren's syndrome are discussed.