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Vitamin A deficiency and new bone growth: histologic changes
Author(s) -
Harris S. S.,
Hunt C. E.,
Alvarez C. J.,
Navia J. M.
Publication year - 1978
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1978.tb01582.x
Subject(s) - guinea pig , retinoic acid , vitamin , bone formation , pathology , animal model , endocrinology , chemistry , biology , medicine , biochemistry , gene
Using a standardized guinea pig model system, the histologic appearance of newly formed bone from vitamin A deficient, vitamin A adequate and retinoic acid treated animals was compared. Microscopic examination of the histologic sections of bone collected from vitamin A deficient guinea pigs indicated the presence of highly cellular and loosely woven bone spicules. This model system is an osteoblastic model, since osteoclasts are essentially absent in tissue formed in 14‐day implants. Thus, new bone formation in the vitamin A deficient guinea pig reveals morphologic changes which are principally mediated through the osteoblastic process.