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Immunopathology of Sjögren‐like * disease in IMZB/NZW mice
Author(s) -
Keyes Gordon G.,
Vickers Robert A.,
Kersey John H.
Publication year - 1977
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1977.tb01651.x
Subject(s) - concanavalin a , immunopathology , immunology , spleen , lipopolysaccharide , autoimmune disease , lymphatic system , endocrinology , salivary gland , medicine , ratón , biology , pathology , in vitro , antibody , biochemistry
In vitro responsiveness of spleen cells from NZB/NZW (B/W) female mice, aged 2 through 40 weeks, to the mitogens phytohemagglutinin (PHA), concanavalin‐A (Con‐A) and lipopolysaccharide (LPS) was determined. An age‐related decline in proliferative response of splenic cells was found; this decline correlated with the age of onset and progression of lymphoid infiltration in lacrimal and salivary glands in the mice. The worsening with age of this lymphoid infiltrate, coupled with the decline in responsiveness to mitogens, suggests a complex immunopathologic process with destruction of glands terminating in a disease similar to the Sjögren syndrome in humans.