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Experimentally induced cleft palates and prophylactic studies in Swiss mice
Author(s) -
Metah Date,
Reznik Gerd,
Schilegel Dieter
Publication year - 1976
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1976.tb01767.x
Subject(s) - medicine , pregnancy , teratology , surgery , gestation , biology , genetics
. In order to examine its prophylaetic eflect, Aetihaemyl® (Solcoseryl®) was administered to pregnant Swiss mice at various intervals before and after i. p. treatment with 30 mg/kg b. w. Endovan®: the optimal time for administration of the latter was found to be the 11.5.th day of pregnancy. A significant reduction ( P ≤0.01) of the rate of experimentally induced cleft malformations, as well as other types of abnormalities of the head area, was demonstrated in comparison to the control groups. These results were even more pronounced when the mother animals were treated in the following manner: 1/10 LD 50 (19.7 ml kg b. w.) of Actihaemy® 1 day. 10 and 5 min before Endoxan, followed by similar closes 5, 10 min and 2 days afterwards. Three prophylactic groups, from a total of 20, demonstrated a significant ( P ≤0.01) reduction in the cleft palate rate. Three additional groups showed reductions of more than 60(illegible) of enophthalmuses and over 25 (illegible) of encephaloceles.