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Ultrastructural observations of the oral mucosa in Anderson‐Fabry disease
Author(s) -
Archard H. O.,
Brindley H. P.
Publication year - 1975
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1975.tb01867.x
Subject(s) - ultrastructure , cytoplasm , pathology , epithelium , glycosphingolipid , fabry's disease , oral mucosa , lamellar granule , electron microscope , fabry disease , biology , chemistry , anatomy , microbiology and biotechnology , medicine , disease , physics , biochemistry , optics
. Electron microscopic study of oral mucosa from a patient with Anderson‐Fabry disease (glycosphingolipid lipidosis) revealed lamellar and membranous osmiophilic intra‐cytoplasmic inclusions having a periodicity of 4.5 nanometers. These were observed chiefly in reticulo‐endothelial cells as membrane bound and occasionally unbound bodies. They could also be observed within the cytoplasm of squamous epithelial cells, particularly of the stratum germinativum. Morphologic features in endothelial and epithelial cells are described.