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Cyclic AMP content of gingival fluid in women taking oral contraceptives
Author(s) -
Grower Marvin F.,
Lyon Douglas R.,
Levin Marvin P.,
Chandler Dorothy W.
Publication year - 1975
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1975.tb01746.x
Subject(s) - saliva , medicine , radioimmunoassay , pill , menstrual cycle , dentistry , oral contraceptive pill , endocrinology , hormone , family planning , population , research methodology , environmental health , pharmacology
. Gingival fluid samples were collected from 12 healthy adult women who ranged in age from 19 to 34 years. Seven subjects with normal menstrual cycles who received no medications acted as controls while five subjects who had been using oral contraceptives for a minimum of 17 months constituted the experimental group. The women using birth control pills showed a 53% increase in the gingival fluid volume versus the controls. Radioimmunoassay revealed a mean concentration of cyclic adenosine monophosphate (cAMP) in the gingival fluid of 3.8.10 −6 M in the controls and 1.9.10 −6 M in subjects using oral contraceptives, although the total amount of cAMP present in the fluid from both groups was equal. These gingival fluid cAMP levels were a hundredfold higher than those measured in serum and saliva.