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Serum inhibition of gingival collagenase
Author(s) -
BirkedalHansen Henning,
Cobb Charles M.,
Taylor Robert E.,
Fullmer Harold M.
Publication year - 1974
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1974.tb01723.x
Subject(s) - collagenase , chemistry , microbial collagenase , macroglobulin , enzyme , enzyme inhibitor , microbiology and biotechnology , biochemistry , biology
. Collagenases derived from bovine and human gingiva are inhibited effectively by serum. In bovine and human serum fractionated by gel chromatography, α 2 ‐macroglobulin is the only significant inhibitor of gingival collagenase. α 1 ‐Antitrypsin inhibited collagenase only in very high concentration and was several hundred‐fold less effective than α 2 ‐macroglobulin. Inhibition of gingival collagenase with α 2 ‐macroglobulin is accompanied by the formation of an enzyme‐inhibitor complex, which has retained no collagenolytic activity.