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A preliminary report on the feeding of cynomolgus monkeys ( Macaca fascicularis ) with a high‐sugar high‐fat diet for 33 weeks
Author(s) -
Mubiru James N.,
GarciaForey Magdalena,
Higgins Paul B.,
Hemmat Peggah,
Cavazos Nicole E.,
Dick Edward J.,
Owston Michael A.,
Bauer Cassondra A.,
Shade Robert E.,
Comuzzie Anthony G.,
Rogers Jeffrey
Publication year - 2011
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.2011.00495.x
Subject(s) - endocrinology , medicine , cholesterol , biology , obesity , trunk , metabolic syndrome , blood sugar , high density lipoprotein , body weight , physiology , diabetes mellitus , ecology
Abstract Background The metabolic syndrome is common in populations exposed to a typical Western diet. There is a lack of an animal model that mimics this condition. Methods We fed 15 cynomolgus monkeys ad libitum a high‐sugar high‐fat (HSHF) diet for 33 weeks. Body weight, body composition, serum lipids, and insulin were measured at baseline and at 33 weeks. Results The animals tolerated the HSHF diet very well. In the intervention group, total serum cholesterol and low‐density lipoprotein cholesterol were 3‐ and 5‐fold higher, respectively, at 33 weeks as compared with their baseline levels. Serum high‐density lipoprotein cholesterol and triglycerides were not significantly affected. Dual‐energy X‐ray absorptiometry (DXA) analysis of the intervention group indicated that the trunk fat mass increased by 187% during this period. Conclusions Cynomolgus monkeys should be a useful model for investigating the interactions of diet and other factors such as genetics in the development of the metabolic syndrome.