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ORIGINAL ARTICLE: AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV‐1157ipd3N4
Author(s) -
García Anapatricia,
Siddappa Nagadenahalli B.,
Li Qingsheng,
Haase Ashley T.,
Paul Katherine,
Stroud Fawn,
Zhang Xiaodong,
Fountain Jack A.,
Villinger François,
Novembre Francis J.,
Else James G,
Evan Secor W.,
Ruprecht Ruth M.
Publication year - 2010
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.2010.00416.x
Subject(s) - viremia , rhesus macaque , simian immunodeficiency virus , virology , biology , coagulopathy , optic neuritis , blindness , pathology , medicine , immunology , virus , multiple sclerosis , optometry
A Chinese rhesus macaque infected with the pathogenic CCR5‐tropic clade C simian‐human immunodeficiency virus, SHIV‐1157ipd3N4, had persistent viremia, depletion of CD4 + T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV‐infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.