Premium
Spontaneous pathology of the baboon endocrine system
Author(s) -
GuardadoMendoza R.,
Dick Jr E.J.,
JimenezCeja L.M.,
Davalli A.,
Chavez A.O.,
Folli F.,
Hubbard G.B.
Publication year - 2009
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.2009.00384.x
Subject(s) - pathology , thyroid , endocrine system , medicine , adenoma , pancreas , pituitary adenoma , amyloidosis , hyperplasia , endocrinology , hormone
Background Study of endocrine pathology in animal models is critical to understanding endocrine pathology in humans. Methods We evaluated 434 endocrine‐related diagnoses from 4619 baboon necropsies, established the incidence of spontaneous endocrine pathology, and analyzed the clinical and biochemical data associated with the individual cases. Results The most common diagnoses in descending order, were pancreatic islet cell amyloidosis (n = 259), ovarian cysts (n = 50), pituitary adenoma (n = 37), pancreatic islet cell adenoma (n = 20), granulosa cell tumor (n = 15), thyroid adenoma (n = 11), adrenal hyperplasia (n = 10), thyroid carcinoma (n = 8), and pheochromocytoma (n = 6). The incidence of pancreatic islet cell amyloidosis progressively increased with age. Pheochromocytomas were associated with renal and heart failure. The incidence of pancreatic islet cell amyloidosis and adrenal pathology was similar to humans; the incidence of pituitary adenoma and thyroid pathology was lower than in humans. Conclusions Endocrine disease in baboons is common and shares clinical and biochemical characteristics with endocrine disease in humans.