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Differential pathogenicity of SHIV SF162 P4 infection in pig‐tailed and rhesus macaques
Author(s) -
Polacino Patricia,
Larsen Kay,
Galmin Lindsey,
Suschak John,
Kraft Zane,
Stamatatos Leonidas,
Anderson David,
Barnett Susan W.,
Pal Ranajit,
Bost Kristen,
Bandivdekar A.H.,
Miller Christopher J.,
Hu ShiuLok
Publication year - 2008
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.2008.00325.x
Subject(s) - viremia , rhesus macaque , infectivity , biology , virology , macaque , immunology , pathogenicity , viral load , simian immunodeficiency virus , virus , microbiology and biotechnology , paleontology
Background Differential pathogenicity has been observed in cynomolgus and rhesus macaques following primate lentivirus infection. However, little is known about the comparative susceptibility of pig‐tailed macaques to lentivirus infection and diseases. Methods We compared the in vivo infectivity and pathogenicity of a CCR5‐tropic SHIV SF162 P4 after intravenous, intravaginal or intrarectal inoculation in rhesus and pig‐tailed macaques. Plasma viral load, peripheral blood CD4 + T cell counts and clinical signs were monitored. Results Both rhesus and pig‐tailed macaques are similarly susceptible to SHIV SF162 P4 infection by intravenous and mucosal routes. However, infection was significantly more robust in pig‐tailed macaques than in rhesus, resulting in persistent viremia in 9/21 pig‐tails vs. 2/24 rhesus ( P < 0.013) and severe CD4 + T‐cell depletion in 2/21 pig‐tails (vs. none in rhesus). Conclusions Together with earlier observations, our findings underscore the importance of considering host genetic and immunological factors when comparing vaccine efficacy in different macaque species.