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Adenoviral hepatitis in a SIV‐infected rhesus monkey ( Macaca mulatta )
Author(s) -
Zöller Martina,
MätzRensing Kerstin,
Kaup FranzJosef
Publication year - 2008
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.2008.00295.x
Subject(s) - basophilic , virology , simian immunodeficiency virus , anorexia , hepatitis , biology , adenovirus infection , virus , pathology , viremia , medicine
Background A 5‐year‐old female rhesus monkey infected with simian immunodeficiency virus became clinically suspicious with anorexia, increasing weakness and apathy eighty‐five weeks after the tonsillar virus inoculation and was euthanised due to a poor prognosis. Methods and Results Postmortal examinations revealed a severe multifocal to coalescing necotizing hepatitis with numerous intranuclear basophilic inclusion bodies. Transmission electron microscopy of the liver resulted in the finding of adenovirus like particles arranged in paracrystalline arrays within the nuclei of hepatocytes. Conclusion The SIV infected rhesus monkey suffered from an adenovirus included necortizing hepatitis, an extremely rare organ manifestation of adenovirus infection in nonhuman primates.