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Spontaneous pancreatic islet cell tumor in a black and white colobus monkey ( Colobus guereza kikuyuensis )
Author(s) -
Hobson David J.,
Turner Patricia V.
Publication year - 2008
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.2007.00259.x
Subject(s) - pathology , chromogranin a , biology , pancreas , synaptophysin , ataxia , anatomy , medicine , immunohistochemistry , endocrinology , neuroscience
A 12‐year‐old, male black and white colobus monkey ( Colobus guereza kikuyuensis ) from a small community zoo presented with a 6‐month history of mild, slowly progressive ataxia and paresis culminating in an acute episode of recumbency, depression, and seizures. The animal was humanely euthanatized. Gross post‐mortem examination revealed significant abnormalities including diffuse pallor of the carcass and a firm, pale, 8‐cm diameter mass, adherent to the serosa of the proximal duodenum and colon, and embedded within the pancreas and mesenteric root. Histologically, the mass had characteristics of a neuroendocrine or endocrine tumor. Immunohistochemical stains for chromogranin, synaptophysin, insulin, and glucagon were positive, confirming the diagnosis of a mixed pancreatic islet cell tumor. These tumors are rare in all species except ferrets and unreported previously in colobus monkeys.