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Biochemical and white blood cell profiles of baboon neonates consuming formulas with moderate and high dietary long‐chain polyunsaturated fatty acids
Author(s) -
Hsieh A.T.,
Anthony J.C.,
DiersenSchade D.A.,
Nathanielsz P.W.,
Thomas Brenna J.
Publication year - 2008
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.2007.00248.x
Subject(s) - docosahexaenoic acid , polyunsaturated fatty acid , baboon , arachidonic acid , white blood cell , triglyceride , eicosapentaenoic acid , long chain , medicine , red blood cell , biology , physiology , endocrinology , fatty acid , cholesterol , zoology , biochemistry , chemistry , enzyme , polymer science
Background Clinical chemistry and complete blood count (CBC) values were determined in 14 term baboons ( Papio species) consuming formula with moderate or high levels of dietary long‐chain polyunsaturated fatty acids (LCPUFA) from 2–12 weeks of age. Method Neonates were randomized to three groups: C: Control, no LCPUFA; L: 0.33% docosahexaenoic acid (DHA)/0.67% arachidonic acid (ARA) (w/w); L3:1.00% DHA/0.67% ARA (w/w). Blood chemistries were assessed at 6 and 12 weeks and CBC parameters were measured at 2, 4, 8, 10, 12 weeks of age. Results Dietary LCPUFA had significant effects on serum triglyceride (C > L,L3) and calcium (L > C,L3). No other significant effects of diet were detected; pooled values are presented for all other parameters. Conclusion These data provide longitudinal biochemical and white cell/platelet/immunological data on LCPUFA‐fed baboons over the first 12 weeks of life. Data ranges are similar to reference data in cases for which values exist and hematological changes reflect trends observed during human neonatal development.