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Immunogenicity and protective efficacy of Gag/Pol/Env vaccines derived from temporal isolates of SIVmne against cognate virus challenge
Author(s) -
Polacino Patricia,
Cleveland Brad,
Zhu Yongde,
Kimata Jason T.,
Overbaugh Julie,
Anderson David,
Hu ShiuLok
Publication year - 2007
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.2007.00243.x
Subject(s) - immunogenicity , biology , virology , virus , clone (java method) , immunity , macaque , antigen , immune system , immunology , genetics , gene , ecology
Background We used the SIVmne model to examine the relative immunogenicity and protective efficacy of vaccines derived from temporal isolates of lentivirus infection. SIVmne170 is a molecular clone isolated from a pig‐tailed macaque 170 weeks after inoculation with SIVmneCL8. Methods We immunized pig‐tailed macaques with Gag/Pol/Env vaccines derived from CL8 or 170 and examined their protective efficacy against CL8, 170, or chimeras 8/170 and 170/8, containing the 5′ or 3′ half of the respective parental genomes. Results As expected, CL8 vaccines protected animals against the CL8, but not the 170 virus. Surprisingly, 170 vaccines not only failed to protect against the 170 virus, but also the less pathogenic CL8. Chimeric virus challenges revealed that the envelope antigen of CL8 represents an important target for protective immunity. Conclusions These results underscore the potential importance of targeting transmitted viruses through judicious choice of immunogens from early isolates for vaccine development.