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Acute neuropathogenicity with experimental infection of equine herpesvirus 9 in common marmosets ( Callithrix jacchus )
Author(s) -
Kodama A.,
Yanai T.,
Yomemaru K.,
Sakai H.,
Masegi T.,
Yamada S.,
Fukushi H.,
Kuraishi T.,
Hattori S.,
Kai C.
Publication year - 2007
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.2007.00220.x
Subject(s) - callithrix , encephalitis , marmoset , olfactory bulb , biology , pathology , immunohistochemistry , virology , virus , immunology , medicine , central nervous system , neuroscience , paleontology
Background Equine herpesvirus 9 (EHV‐9) is a new neurotropic equine herpesvirus which induced encephalitis in a variety of animals. However, there was no information on the susceptibility of EHV‐9 in primates. Methods To assess the infectivity of EHV‐9, four common marmosets ( Callithrix jacchus ) were inoculated by the nasal route with 10 6 plaque‐forming units of EHV‐9. Results and conclusions All of the inoculated animals exhibited various neurological signs progressing to collapse. Histologically, the affected animals had severe encephalitis characterized by neuronal degeneration and necrosis with intranuclear inclusion bodies, which extended from the olfactory bulb to the rhinencephalon and piriform lobe. Immunohistochemistry revealed EHV‐9 antigens in degenerating neuronal cells. The nasal cavity had severe necrotizing rhinitis with prominent intra‐nuclear inclusion bodies in the olfactory mucosa. These findings indicate that the marmosets are susceptible to EHV‐9.