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Widespread occurrence of antibodies against circumsporozoite protein and against blood forms of Plasmodium vivax , P. falciparum and P. malariae in Brazilian wild monkeys
Author(s) -
Duarte Ana Maria R. de C.,
Porto Maura A.L.,
Curado Izilda,
Malafronte Rosely S.,
Hoffmann Erika H.E.,
Oliveira Salma G.,
Silva Adriana M.J.,
Kloetzel Judith K.,
Gomes Almério de C.
Publication year - 2006
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.2006.00148.x
Subject(s) - circumsporozoite protein , plasmodium vivax , malaria , plasmodium falciparum , biology , antibody , virology , plasmodium malariae , plasmodium (life cycle) , protozoa , parasite hosting , immunology , microbiology and biotechnology , world wide web , computer science
Background A survey of malaria antibodies was carried out over 7 years and a total of 777 serum samples from wild monkeys were collected in three distinct ecological areas of Brazil where autochthonous malaria has been reported: the ‘Cerrado’ (similar to savanna), the Atlantic Forest and the Atlantic Semideciduous Forest. Methods We carried out enzyme‐linked immunosorbent assay to investigate the presence of IgG antibodies against peptides of the circumsporozoite protein (CSP) repeat region of ‘classic’ Plasmodium vivax , P. vivax VK247, human P. vivax ‐like/ P. simiovale , P. brasilianum / P. malariae and P. falciparum. We also carried out immunofluorescence assay with asexual forms of P. vivax , P. malariae and P. falciparum . Results The high prevalence of antibodies against CSP in all areas indicates that the monkeys had intense contact with sporozoites from infected anophelines. The immune response against asexual forms of Plasmodium in the monkeys from the Atlantic Forest indicates the development of the infection. Conclusions We discuss the possibility of monkeys being malaria reservoirs in non‐endemic areas.