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Early virological events in various tissues of newborn monkeys after intrarectal infection with pathogenic simian human immunodeficiency virus
Author(s) -
Miyake Ariko,
Ibuki Kentaro,
Suzuki Hajime,
Horiuchi Reii,
Saito Naoki,
Motohara Makiko,
Hayami Masanori,
Miura Tomoyuki
Publication year - 2005
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.2005.00127.x
Subject(s) - virology , simian immunodeficiency virus , biology , virus , immunodeficiency , immunology , viral replication , cd3 , simian , immune system , cd8
Children infected with human immunodeficiency virus type 1 often have higher viral loads and progress to acquired immunodeficiency syndrome more rapidly than adults. In our previous study of simian–human immunodeficiency virus (SHIV)‐infected adult monkeys, immature CD4CD8 double‐positive T cells in the thymus and jejunum decreased faster than mature CD4 single‐positive T cells. Here, we examined the effect of virus replication on immature T cells from the same SHIV‐inoculated newborn monkeys having more immature T cells than adults. The infectious viruses were more abundantly detected in the thymus than in other tissues at both 13 and 26 days post‐infection (dpi). However, mature CD4 + T cells in the thymus declined after 13 dpi and immature CD3 − CD4 single‐positive T cells remained at 26 dpi. These results suggested that many immature CD4 + T cells in the thymus of newborns support the production of infectious viruses even after the depletion of mature CD4 + T cells.