Premium
Hematologic and lymphocyte immunophenotypic reference values for normal rhesus monkey ( Macaca mulatta ) umbilical cord blood; gravidity may play a role in study design
Author(s) -
Rogers Linda B.,
Kaack M. Bernice,
Henson Michael C.,
Rasmussen Terri,
Henson Elizabeth,
Veazey Ronald S.,
Krogstad Donald J.,
Davison Billie B.
Publication year - 2005
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.2005.00104.x
Subject(s) - umbilical cord , hematology , medicine , immune system , pregnancy , cord blood , fetus , lymphocyte , immunology , flow cytometry , physiology , andrology , obstetrics , biology , genetics
Hematology and flow cytometry reference values for rhesus umbilical cord blood (UCB) were established in 17 healthy infant rhesus monkeys delivered by elective cesarean section 10 days preterm. The infants were born to age matched, singly caged primigravid or secundigravid dams. The hematology and flow cytometry values were determined by automated cell counter and by FACS. No significant differences were observed with respect to infant gender. With respect to gravida, the primigravid infants had a significantly higher percentage ( P = 0.05) of CD20 + B lymphocytes in UCB. These results provide useful reference values for future studies of maternal – fetal disease transmission, vaccine and drug evaluation in non‐human primate pregnancy, as well as fetal programming and immune modulation, gene therapy and the use of UCB as a source of stem cells for research and transplantation. Importantly, our results suggest that maternal gravidity may be an important variable to consider.