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Perinatal transmission of SHIV‐SF162P3 in Macaca nemestrina
Author(s) -
Jayaraman Pushpa,
Mohan Deepika,
Polacino Patricia,
Kuller LaRene,
Sheikh Nadeem,
BielefeldtOhmann Helle,
Richardson Barbra,
Anderson David,
Hu ShiuLok,
Haigwood Nancy L.
Publication year - 2004
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.2004.00079.x
Subject(s) - viremia , in utero , macaca nemestrina , macaque , medicine , transmission (telecommunications) , rhesus macaque , antibody , neutralizing antibody , pregnancy , obstetrics , immunology , physiology , fetus , biology , paleontology , electrical engineering , genetics , engineering
We developed a SHIV/macaque model of transmission from infected dams to their infants. Ten pregnant dams were infected intravenously with 100 MID 50 of macaque‐titered SHIV‐SF162P3 during the second trimester. Nine infants were born; the seven surviving beyond day of birth suckled for 6 months. Four of nine infants were infected (transmission rate = 44.4%), with one infection in utero , and three intrapartum and/or immediately post‐birth via suckling. Varying levels of binding and neutralizing antibodies were transplacentally transferred to infants. Passive antibodies were detected in plasma on the day of birth and persisted for 5 weeks. Infants infected at or after birth controlled acute and post‐acute viremia. Exposure to maternal SHIV‐SF162P3 during birth and suckling in the presence of autologous maternal neutralizing antibodies may have affected transmission or pathogenesis in the infants. This transmission model can allow investigation of key parameters involved in perinatal transmission of HIV.