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Dichotomy between CD1a+ and CD83+ dendritic cells in lymph nodes during SIV infection of macaques
Author(s) -
Söderlund Johan,
Nilsson Charlotta,
Loré Karin,
CastanosVelez Esmeralda,
Ekman Marianne,
Heiden Thomas,
Biberfeld Gunnel,
Andersson Jan,
Biberfeld Peter
Publication year - 2004
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.2003.00053.x
Subject(s) - simian immunodeficiency virus , lymph , dendritic cell , immunology , biology , lymph node , lymphatic system , immunodeficiency , virology , virus , antigen , immune system , pathology , medicine
The prevalence and differentiation of dendritic cells (DC) in lymphoid tissue of simian immunodeficiency virus (SIV)‐infected cynomolgus monkeys was studied during disease progression. Lymph node biopsies were consecutively obtained from clinical rapid and slow progressors until the development of disease consistent with simian acquired immunodeficiency syndrome (sAIDS) occurred. Quantitative evaluation of CD1a+ DC and the expression of DC antigens related to maturation (CD83, DC‐LAMP and S100b) were performed at the single cell level by in situ image analysis. Despite a persistent prevalence of CD1a+ DC in lymphoid tissue during disease progression, there was a subsequent drop of mature CD83+, DC‐LAMP+ and S100b+ DC, correlating with the decline of CD4+ T cells in blood. Thus, disease progression to sAIDS was associated with impaired maturation of DC, and lack of CD83, DC‐LAMP and S100b expression.