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Comparative analysis of natural killer cell activity, lymphoproliferation and lymphocyte surface antigen expression in nonhuman primates housed at the CIRMF Primate Center, Gabon
Author(s) -
PoatyMavoungou Virginie,
Onanga Richard,
Yaba Philippe,
Delicat André,
Dubreuil Guy,
Mavoungou Elie
Publication year - 2001
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.2001.300104.x
Subject(s) - biology , primate , immunology , cercopithecus aethiops , immune system , simian immunodeficiency virus , antigen , virology , peripheral blood mononuclear cell , baboon , monoclonal antibody , african green monkey , antibody , virus , biochemistry , neuroscience , in vitro , endocrinology
Six different species of nonhuman primates housed at the CIRMF Primate Center, cynomolgus monkeys ( Macaca fascicularis ), rhesus monkeys ( Macaca mulatta ), mandrills ( Mandrillus sphinx ), vervets ( Cercopithecus aethiops pygerythrus ), chimpanzees ( Pan troglodyte ) and baboons ( Papio hamadryas ), were evaluated for their natural killer cell activity and for the ability of their peripheral blood mononuclear cells to proliferate in response to known mitogens (concanavalin A, phytohemagglutinin and staphylococcal enterotoxin A) and to react with a panel of mouse monoclonal antibodies directed against human leukocyte surface antigens. Basic information on normal immune functions in these primates is important because of their use as experimental animal models for the study of human diseases such as acquired immunodeficiency syndrome (AIDS), hepatitis, loiasis and malaria.