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Localization of immunoreactive testosterone and 3β‐hydroxysteroid dehydrogenase/Δ 5 ‐Δ 4 isomerase in cynomolgus monkey ( Macaca fascicularis ) testes during postnatal development
Author(s) -
Liang JiHong,
Sankai Tadashi,
Yoshida Takashi,
Cho Fumiaki,
Yoshikawa Yasuhiro
Publication year - 1999
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1999.tb00252.x
Subject(s) - sertoli cell , immunocytochemistry , testosterone (patch) , endocrinology , medicine , biology , testicle , leydig cell , spermatogenesis , hormone , luteinizing hormone
The age‐related expression of testosterone and 3β‐HSD in the testes of cynomolgus monkeys was detected using light‐microscopic immunocytochemistry. Intense deposits of immunoreactive testosterone were labeled in parts of Leydig cells in neonatal, late infantile, pubertal, and adult testes, and only a few Leydig cells in early infantile testes. The immunoreactive 3β‐HSD was labeled in parts of Leydig cells and in all Sertoli cells in neonatal, late infantile, pubertal, and adult testes, whereas only a few Leydig cells, but no Sertoli cells, were labeled in early infantile testes. The fluctuations of testosterone and 3β‐HSD expression in testes correlated well with those already observed plasma testosterone levels during postnatal development in cynomolgus monkeys.