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SIVrcm infection of macaques
Author(s) -
Smith Stephen M.,
Makuwa Maria,
Lee Fred,
Gettie Agegnehu,
Russo Christine,
Marx Preston A.
Publication year - 1998
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1998.tb00232.x
Subject(s) - virology , clone (java method) , primate , biology , lentivirus , cytopathic effect , rhesus macaque , macaque , peripheral blood mononuclear cell , simian immunodeficiency virus , human immunodeficiency virus (hiv) , non human primate , immunology , virus , in vitro , viral disease , genetics , gene , evolutionary biology , paleontology , neuroscience
In a prior report, we described the isolation and characterization of SIVrcm, a distinct primate lentivirus found in a household pet Red‐Capped Mangabey (RCM) in Gabon. SIVrcm is divergent from HIV‐1 and HIV‐2/SIV families of primate lentiviruses. In this report, additional in vitro replication studies and the results of SIVrcm infection in macaques are presented. SIVrcm causes little cytopathic effedct in Molt 4 Clone 8 cells and in rhesus and human PBMCs. In vivo, SIVrcm is non‐pathogenic after 200 days in rhesus macaques and after one year in cynomolgous macaques, but does cause a chronic infection in both macaques.