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Chimeric SHIV that causes CD4 + T cell loss and AIDS in rhesus macaques
Author(s) -
Joag Sanjay V.,
Li Zhuang,
Wang Chunyang,
Jia Fenglan,
Foresman Larry,
Adany Istvan,
Pinson David M.,
Stephens Edward B.,
Narayan Opendra
Publication year - 1998
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1998.tb00227.x
Subject(s) - rhesus macaque , virology , pneumonia , immunology , chimera (genetics) , biology , simian immunodeficiency virus , animal model , inoculation , t cell , medicine , human immunodeficiency virus (hiv) , immune system , biochemistry , gene , endocrinology
By animal to animal passage in rhesus and pig‐tailed macaques, we developed a rhesus model of HIV‐1 disease in humans. Rhesus macaques infected with a cell‐free stock of SHIV KU‐2 developed CD4 + T cell loss, primary lentiviral encephalitis and pneumonia, and AIDS. Six of nine rhesus macaques died within eight months post‐inoculation, while the remaining three are at five, five, and eight months post‐inoculation, respectively. Animals infected by either mucosal or parenteral routes of infection had a similar course of infection.