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CD4/GP120 mac251 interaction induces phospholipase A2 (PLA 2 ) activation in cynomolgus monkey lymphocytes
Author(s) -
Mavoungou Elie,
PoatyMavoungou Virginie
Publication year - 1998
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1998.tb00071.x
Subject(s) - glycoprotein , simian immunodeficiency virus , lipid bilayer fusion , vesicular stomatitis virus , macaque , viral envelope , rhesus macaque , biology , virology , microbiology and biotechnology , chemistry , virus , paleontology
Cynomolgus monkey are susceptible to infection with select simian immunodeficiency virus (SIV). We investigated the early interactions between SIV envelope glycoproteins (gp120 mac251 ) and macaque lymphocytes. Our results demonstrate that the soluble viral glycoprotein induce a specific phospholipase A 2 (PLA 2 ) activation in lymphocytes through CD4. This PLA 2 activation, induced after envelope glycoprotein‐CD4 interaction, because of its locally destabilizing membrane effect, may have important implications for preparing the lymphocyte membrane for fusion with the viral particle. However, this effect is not sufficient to accomplish fusion. These data indicate that the specific step of fusion may be downstream from PLA 2 activation.