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A model for the maturation of protective antibody responses to SIV envelope proteins in experimentally immunized monkeys
Author(s) -
Cole Kelly Stefano,
Rowles Jennifer L.,
MurpheyCorb Michael,
Clements Janice E.,
Robinson James,
Montelaro Ronald C.
Publication year - 1997
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1997.tb00319.x
Subject(s) - simian immunodeficiency virus , virology , biology , antibody , virus , immunity , immune system , heterologous , immunology , viral envelope , attenuated vaccine , genetics , virulence , gene
Studies using live attenuated virus vaccines in the simian immunodeficiency virus (SIV) rhesus macaque model have demonstrated broad protection against experimental challenge. Protection in these studies was found to be critically dependent on the length of time postvaccination, suggesting that protective immunity involves a necessary maturation of immune responses. The current study characterizes the evolution of protective envelope‐specific antibody responses from monkeys inoculated with the highly attenuated SIV/17E‐C1 virus vaccine. For comparison, the same antibody assays were used to characterize the properties of SIV envelope‐specific antibodies elicited by inactivated whole virus and envelope subunit vaccines that failed to provide protection from experimental virus challenge. Results of these studies identify a continuous and complex maturation of envelope‐specific antibody responses during the first six to eight months postinfection. Furthermore, the time required for maturation of SIV envelope‐specific antibodies parallels the time required for the development of protective immunity against experimental challenge with heterologous strains of SIV. While no single immune correlate of protection has been identified, we suggest that a combination of antibody parameters may serve as prognostic indicators in the development of candidate AIDS vaccines.