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Safety and immunogenicity of intramuscular and intravaginal delivery of HIV‐1 DNA constructs to infant chimpanzees
Author(s) -
Bagarazzi Mark L.,
Boyer Jean D.,
Javadian M. AM,
Chattergoon Michael,
Dang Kesen,
Kim Grace,
Shah Jyoti,
Wang Bin,
Weiner David B.
Publication year - 1997
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1997.tb00316.x
Subject(s) - immunogenicity , immunization , dna vaccination , vaccination , virology , immunology , human immunodeficiency virus (hiv) , medicine , biology , antibody
Any global strategy for controlling the human immunodeficiency virus (HIV) epidemic is likely to rely heavily on immunization of infants and children. Given the well‐documented differences in children's responses to traditional vaccines, we initiated this study to extend our findings on DNA vaccination of adult chimpanzees to immunologically immature infant chimpanzees. Our findings were consistent with our previous work in adults as we observed that the DNA vaccines used here were both well tolerated and immunogenic within weeks of the initial vaccination.