Premium
A malignant astrocytoma containing simian virus 40 DNA in a macaque infected with simian immunodeficiency virus
Author(s) -
Hurley John P.,
Ilyinskii Petr O.,
Horvath Christopher J.,
Simon Meredith A.
Publication year - 1997
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1997.tb00049.x
Subject(s) - simian immunodeficiency virus , biology , virology , simian , macaque , rhesus macaque , virus , glial fibrillary acidic protein , synaptophysin , microbiology and biotechnology , pathology , immunohistochemistry , immunology , medicine , paleontology
Polyomaviruses have proven oncogenicity in nonhost experimental animals; however, studies concerning the association between human brain tumors and simian and human polyomaviruses have yielded inconclusive results. We examined the relationship of SV40 to a malignant astrocytoma found in the right frontal lobe of a pigtail macaque ( Macaca nemestrina ) infected with simian immunodeficiency virus (SIV). Consistent with the histologic diagnosis, the tumor was immunoreactive with antibodies to S‐100 protein, vimentin, and glial fibrillary acidic protein, but negative for neurofilament protein, synaptophysin, neuron‐specific enolase, and chromogranin A. At the time of SIV inoculation, the animal was seropositive for SV40. Polymerase chain reaction assay of tumor DNA, but not normal brain DNA, yielded a 300 base‐pair fragment corresponding to the carboxy‐terminal coding region (C‐terminus) of the large T antigen gene of SV40, suggesting an association with the tumor.