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Relation between phylogeny of African green monkey CD4 genes and their respective simian immunodeficiency virus genes
Author(s) -
Fomsgaard Anders,
MüllerTrutwin Michaela C.,
Diop Ousmane,
Hansen Jan,
Mathiot Christian,
Corbet Sylvie,
BarréSinoussi Francoise,
Allan Jonathan S.
Publication year - 1997
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1997.tb00043.x
Subject(s) - biology , simian immunodeficiency virus , african green monkey , phylogenetic tree , subspecies , phylogenetics , macaque , rhesus macaque , gene , virology , old world , primate , virus , genetics , zoology , evolutionary biology , ecology
An apparent species‐specific relatedness of SIV agm suggests a coevolution with their natural hosts. However, the exact species or subspecies classification of African green monkeys, AGM, is uncertain because current classification schemes rely on phenotype markers, while more definitive genetic data are lacking. In this study, the CD4 protein involved in tissue type recognition was genetically cloned and sequenced from PBMC RNA from all AGM species, including Barbados green monkeys (BGM). Phylogenetic trees were constructed that also included genomic CD4 nucleotide sequences from patas, sooty mangabeys, rhesus and pig‐tail macaques, chimpanzees, and humans. Chimpanzees and humans consistently clustered together. Monkeys within the Cercopithecus genus formed a separate cluster which included pata monkeys, supporting its grouping as a member of Cercopithecus . Surprisingly, sooty mangabeys were genetically more closely related to Asian macaques than to other African species, which might explain why macaques are more susceptible to infection by the SIV sm group than to infection by SIV agm or HIV‐1 and why patas, on the other hand, are highly susceptible to SIV agm infection. Based on CD4 genetic data, tantalus, vervets, grivets, and sabaeus formed separate subgroups with BGM grouping closely with vervets. The branching order of the AGM species was related to that of their respective SIV agm env sequences. The study suggests a strong correlation between CD4 phylogeny and the susceptibility of the host species to infection by a specific lentivirus and supports the assumption of a coevolution of SIV agm and AGM. CD4 sequencing is suggested as a relevant method for genetic determination of primate species.