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Immunohistochemical characteristics of the constituents of senile plaques and amyloid angiopathy in aged cynomolgus monkeys
Author(s) -
Nakamura Shinichiro,
Kiatipattanasakul Wijit,
Nakayama Hiroyuki,
Ono Fumiko,
Sakakibara Ippei,
Yoshikawa Yasuhiro,
Goto Naoaki,
Doi Kunio
Publication year - 1996
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/j.1600-0684.1996.tb00213.x
Subject(s) - senile plaques , cerebral amyloid angiopathy , pathology , glial fibrillary acidic protein , apolipoprotein e , amyloid (mycology) , extracellular , immunohistochemistry , pathogenesis , neurite , amyloid beta , astrocytosis , chemistry , biology , alzheimer's disease , medicine , microbiology and biotechnology , biochemistry , dementia , disease , in vitro
In this study, we immunohistochemically examined the several constituents of senile plaques (SPs) and cerebral amyloid angiopathy (CAA) in aged cynomolgus monkeys. Apolipoprotein E (apoE) deposited in all mature plaques and CAA, and in half of the diffuse plaques. Alpha‐1‐antichymotripsin (αACT) deposited in half of the mature plaques and in one third of the CAA. Amyloid precursor protein (APP), ubiquitin (Ub), and microtubule‐associated protein‐2 (MAP‐2) accumulated in the swollen neurites of mature plaques. Glial fibrillary acidic protein (GFAP) was detected in the astrocytes and their processes surrounding the mature plaques. Tau was detected in neither the SPs nor CAA. Therefore, mature plaques involved extracellular Aβ, apoE, and αACT, and also astrocytes and swollen neurites. However, diffuse plaques involved only extracellular Aβ and apoE. Since these features, except for tau, were consistent with those in humans, this animal model will be useful for studying the pathogenesis of cerebral amyloid deposition.